Autophagy and cancer

This is a new cellular mechanism I did not know about: autophagy. Nature's issue of April 12th (I am bit behind I know) has an interesting article in the section Q&A on autophagy and its role in cancer.

Autophagy is the process by which cells degrade faulty or redundant components. It is used by cells when they need to reuse molecules for other uses and also it plays an important role in complementing apoptosis. Both apoptosis and autophagy are connected to cell death but in the case of autophagy cell death is not always the outcome although it can be a substitute when the apoptotic mechanism is crippled. In that case the cell literally eats itself to death.

The image bellow comes from the article. Autophagy has the potential of being useful for cancer supression but also for cancer promotion. The balance is important, too little and you get cell death when the cell cannot produce things it needs by reusing parts of itself. Too much of it and you also get cell death since the cell can eat itself. Altering this balance in a tumour cell could be the source of a new therapy although as usual it is important to remember that cells might evolve mechanisms to avoid the trouble of autophagy, maybe by inactivating the atophagy mechanism all together. Even in that case the tumour cell would be less capable of surviving in situations of stress since it would not be able to recycle material.

Autophagy seems to be a mechanism whose precise role in cancer has not been fully studied yet but could be a promising extra target for a multi target therapy that could hinder cancer evolution and growth.

Lenski et al: Balancing robustness and evolvability

R. Lensi, J. Barrick and C. Ofria. Balancing robustness and evolvability. PLoS Biology, Vol. 4, 12, pp 2190-2193

This paper has not much to do with cancer but I have been interested in evolvability issues for a while so I decided to take a look at it. Tumour evolution has many but not all the features of the evolution involving longer time scales but its evolvability is not a thoroughly investigated topic. That is a shame because it seems that, given enough time, one would expect that tumour cells will not evolve only towards phenotypes that can take better advantage of the environment but also to genotypes that allow evolution to adapt better to that changing environment.

This paper does not explore this but something also interesting: that robustness and evolvability might be desirable but incompatible aims. Robustness can be seen as he ability to counteract change while evolvability represents the capability to adapt. In general it is true that species must strike some sort of compromise between these two abilities since organisms need the robustness provided, for instance, by the DNA repair mechanism but species need mutations that actually allow these organisms to better adapt to the environment. This is not always true and there are cases in which robustness and evolvability can go happily hand by hand. One such case is genomic redundancy. Up to a point, genomic redundancy improves robustness since functionality is kept in more than one location making it less vulnerable but also it helps evolvability since it allows duplicated genes to evolve different functions.

The general rule though is that organisms cannot be entirely robust to change in the form of genetic mutations since such an organism would freeze from an evolutionary point of view and thus subject to become extinct when a fitter rival comes around. I guess that that is a good explanation to cancer, a perfect reproduction mechanism would have not led from simple organisms to humans.

Article in Nature: Driven to Market

Nature has a reputation for publishing academic articles of high-impact (that is, loads of people read nature so articules in nature are widely read and are more likely to be cited by other people which means that Nature becomes better ranked which means that more people buy it which means...), but also they have some nice articles that are more accessible to non specialists and that are written by freelance writers.

Yesterday I was reading one in last week's (I am always late with my issue) entitled "Driven to Market" by Jonah Lehre. The article is about a relatively new field called neuroeconomics which combines both psychology and economics. That does not seem related to the topic of this blog but what it is interesting (to me) is that one of the assumptions that is prevalent in economics and that the practitioners of neuroeconomics bring to question is that humans act guided by reason in order to maximise their own benefit. This is also one of the main assumptions in Game Theory (which is a common tool in Economics). Ironically one of the criticisms that opponents of evolutionary game theory have is that animals are not rational but it seems that reason is an even weaker predictor of the behaviour of humans. One nice example to illustrate that is the game called ultimatum. In this game one player is given, say, 10 euros and told that it has to share it with someone else in such a way that if any of the players is unhappy with the way the money has been split then no one gets anything. If people were rational the first player will always offer 1 euro to the second one knowing that the second one would take whatever he or she is offered since the alternative is to get nothing at all. It seems though that when this game is played by people, deals that seem to be too unfair are always rejected even if that rejection means that the money is lost.